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A post-GWAS replication study confirming the association of

Shaohua YANG,Chao QI,Yan XIE,Xiaogang CUI,Yahui GAO,Jianping JIANG,Li JIANG,Shengli ZHANG,Qin ZHANG,Dongxiao SUN

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4,   Pages 321-330 doi: 10.15302/J-FASE-2014037

Abstract: Among them, the gene is merely 87 bp away from the significant SNP, Hapmap30383-BTC-005848., we report herein genotype-phenotype associations to further validate the genetic effects of the geneBy pooled DNA sequencing of 14 unrelated Holstein sires, a total of 18 with seven novel SNPs were identified

Keywords： GWAS     functional annotation     Chinese Holstein     milk production traits     <i>C14H8orf33i> gene     single nucleotide    

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Development of an H reduction and moderate oxidation method for 3,5-dimethylpyridine hydrogenation in

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 12,   Pages 1807-1817 doi: 10.1007/s11705-022-2243-2

Abstract: Under the same reduction conditions (300 °C in H2), the catalytic activity of the non-<i>in-situi> reduced Ru/C-n catalyst was higher than that of the <i>in-situi> reduced Ru/C-y catalyst.Therefore, an <i>in-situi> H2 reduction and moderate oxidation method was developed to increasei> H2 reduction and moderate oxidation (oxidized at 100 °C).of the <i>in-situi> H2 reduction and moderate oxidized Ru/C-i2 catalyst, the interaction

Keywords： Ru/C catalyst     <i>in-situi> H2 reduction and moderate oxidation     <i>in-situi> reduction     non-<i>in-situi> reduction     hydrogenation of 3     5-dimethylpyridine    

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Protective efficacy of vaccination with NcMIC3 and NcMIC8 against

Taotao ZHANG, Xiao ZHANG, Qun LIU, Jianhai XU, Jing LIU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 2,   Pages 188-196 doi: 10.15302/J-FASE-2019253

Abstract: Several studies have indicated that MIC3 and MIC8 are important adhesion factors and potential vaccinestudy, we evaluated the protective efficacy of recombinant proteins and DNA vaccines of NcMIC3 and NcMIC8.BALB/c mice were immunized with rNcMIC3, rNcMIC8, pcDNA3.1-NcMIC3 and pcDNA3.1-NcMIC8 respectively, andIn addition, mice immunized with rNcMIC3 and rNcMIC8 a had lower parasite burden in brain tissue comparedThese results demonstrate that rNcMIC3 and rNcMIC8 could induce humoral and Th2-type immune response,

Keywords： NcMIC3     NcMIC8     <i>Neospora caninumi>     vaccination    

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Association of gene variants with juvenile amyotrophic lateral sclerosis

Frontiers of Medicine doi: 10.1007/s11684-023-1005-y

Abstract: A variation within <i>TRMT2Bi> (c.1356G>T; p.K452N) was identified to be associated with ALS in a familya high level of ROS were observed functionally in patient-originated lymphoblastoid cell lines and <i>TRMT2Bi> interfering HEK293 cells.Further, <i>TRMT2Bi> variations overexpression cells also displayed decreased ND1.In conclusion, a novel JALS-associated gene called <i>TRMT2Bi> was identified, thus broadening the

Keywords： <i>TRMT2Bi>     amyotrophic lateral sclerosis     mitochondrial complex I     tRNA methylation     reactive oxygen    

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Gene delivery into isolated

Nan Zheng, Ziyuan Song, Yang Liu, Lichen Yin, Jianjun Cheng

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 521-528 doi: 10.1007/s11705-017-1612-8

Abstract: The application of gene delivery materials has been mainly focused on mammalian cells while rarely extendedThis study therefore widens the utilities of helical polypeptide as a unique category of gene deliverymaterials, and may find their promising applications toward plant gene delivery.

Keywords： <i>αi>-helical polypeptide     plant gene delivery     protoplast     intact leaves     transfection    

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A novel aldo-keto reductase gene,

Jinxi HUO, Bing DU, Sifan SUN, Shaozhen HE, Ning ZHAO, Qingchang LIU, Hong ZHAI

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 2,   Pages 206-213 doi: 10.15302/J-FASE-2018225

Abstract: In this study, the gene was isolated from sweet potato.increased significantly (approximately 3-fold) after exposure to 200 mol·L CdCl or 10 mmol·L HIn addition, proline content and superoxide dismutase activity were significantly higher and H O levels

Keywords： cadmium stress     <i>IbAKRi>     <i>Ipomoea batatasi>     sweet potato    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: However, <i>RUNX1i> mutations have been largely under-explored compared with <i>RUNX1i> fusions mainlyi> mutations in AML./i> mutations.Then, based on RNA-seq data from The Cancer Genome Atlas AML cohort, we developed a 300-gene signatureThis study revealed the distinct gene expression pattern of <i>RUNX1i> mutations and the underlying

Keywords： <i>RUNX1i>     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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<i>NES1i>/<i>KLK10i> and <i>hNISi> gene therapy enhanced iodine-131 internal radiation in PC3 proliferation

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 646-657 doi: 10.1007/s11684-018-0643-y

Abstract: gene is thought to be a tumor-suppressor gene.Thus, we supposed to have an “enhanced firepower” effect by combining overexpressed gene therapy andI radiation therapy uptake by overexpressed hNIS protein.therapy and I radiation therapy mediated by overexpressed hNIS protein had the best tumor proliferativethat via inhibition of expression, overexpressed might enhance the effect of radiation therapy of I

Keywords： androgen-independent prostate cancer     normal epithelial cell-specific 1/kallikrein 10     sodium/iodide symporter     radiation therapy     proliferation    

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<i>Ni>-Positive ion activated rapid addition and mitochondrial targeting ratiometric fluorescent probesfor <i>in vivoi> cell H2S imaging

Yan Shi, Fangjun Huo, Yongkang Yue, Caixia Yin

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 64-71 doi: 10.1007/s11705-021-2048-8

Abstract: work, we combine these two groups organically to construct a rapid response site (within 30 s) for HS, and at the same time, a ratiometric fluorescence response is presented throughout the process of HAs such, the lower detection limit can reach 55.7 nmol/L for H S.shows that this probe can be used for the mitochondrial targeted detection of endogenous and exogenous HFinally, this probe application was verified by imaging H S in nude mice.

Keywords： heterocyclic compound     hydrogen sulfide     ratiometric     mitochondrial targeted    

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<i>RR1i> and <i>RR2i> gene deletion affects the immunogenicity of a live attenuated pseudorabies

Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 81-86 doi: 10.15302/J-FASE-2016088

Abstract: In this study, we deleted and genes based on a / / triple gene-deleted pseudorabies virus and tested

Keywords： pseudorabies virus     <i>RR1i> and <i>RR2i>     ribonucleotide reductase     vaccine candidate    

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NO<i>xi> and H2S formation in the reductive zone of air-staged combustion of

Jinzhi CAI, Dan LI, Denggao CHEN, Zhenshan LI

Frontiers in Energy 2021, Volume 15, Issue 1,   Pages 4-13 doi: 10.1007/s11708-020-0804-y

Abstract: China to control NO emission; thus, it is necessary to understand the formation mechanism of NO and HThis paper focused on the investigation of reductive gases in the formation of NO and H S in the reductiveGE) coal and their blends with different mixing ratios were conducted in a drop tube furnace at 1200°C–1400°C with an excessive air ratio of 0.6–1.2.ZD into GE was found to increase not only the coal conversion but also the concentrations of CO and H

Keywords： blended coal combustion     NO<i>x i>formation     H2S formation     air staged combustion    

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<i>H. sinensisi> mycelium inhibits epithelial-mesenchymal transition by inactivating

Li Lu, Haiyan Zhu, Hailin Wang, Huaping Liang, Yayi Hou, Huan Dou

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 313-329 doi: 10.1007/s11684-020-0737-1

Abstract: The medical fungus has been used as a Chinese folk health supplement because of its immunomodulatory properties. Our previous studies established the antifibrotic action of mycelium (HSM) in the lung. The epithelial–mesenchymal transition (EMT) is involved in the pathogenesis of idiopathic pulmonary fibrosis. The present study investigates the role of HSM in mediating EMT during the development of pulmonary fibrosis. HSM significantly inhibits bleomycin (BLM)-induced pulmonary fibrosis by blocking the EMT. In addition, the expression levels of midkine are increased in the lungs of the BLM-induced group. Further analysis of the results indicates that the mRNA level of midkine correlated positively with EMT. HSM markedly abrogates the transforming growth factor β-induced EMT-like phenotype and behavior . The activation of midkine related signaling pathway is ameliorated following HSM treatment, whereas this extract also caused an effective attenuation of the induction of EMT (caused by midkine overexpression) . Results further confirm that oral medication of HSM disrupted the midkine pathway . Overall, findings suggest that the midkine pathway and the regulation of the EMT may be considered novel candidate therapeutic targets for the antifibrotic effects caused by HSM.

Keywords： epithelial−mesenchymal transition     <i>H. sinensisi> mycelium     midkine     pulmonary fibrosis    

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A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 330-338 doi: 10.1007/s11684-022-0933-2

Abstract: To date, four mutations in the <i>GJB6i> gene, G11R, V37E, A88V, and D50N, have been confirmed to causeIn previous studies, the focus has been mainly on gene sequencing, and there has been a lack of researchWe found a novel heterozygous missense variant (c.134G>C:p.G45A) for Clouston syndrome.Our data reveal that a novel variant (c.134G>C:p.G45A) plays a likely pathogenic role in this pedigree

Keywords： Clouston syndrome     whole exome sequencing     <i>GJB6i> gene     novel variant     unique phenotype    

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Chemical poison and regeneration of SCR catalysts for NO<i>xi>

Junhua LI,Yue PENG,Huazhen CHANG,Xiang LI,John C. CRITTENDEN,Jiming HAO

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 3,   Pages 413-427 doi: 10.1007/s11783-016-0832-3

Abstract: Selective catalytic reduction (SCR) of NO with NH is an effective technique to remove NO from stationary sources, such as coal-fired power plant and industrial boilers. Some of elements in the fly ash deactivate the catalyst due to strong chemisorptions on the active sites. The poisons may act by simply blocking active sites or alter the adsorption behaviors of reactants and products by an electronic interaction. This review is mainly focused on the chemical poisoning on V O -based catalysts, environmental-benign catalysts and low temperature catalysts. Several common poisons including alkali/alkaline earth metals, SO and heavy metals etc. are referred and their poisoning mechanisms on catalysts are discussed. The regeneration methods of poisoned catalysts and the development of poison-resistance catalysts are also compared and analyzed. Finally, future research directions in developing poisoning resistance catalysts and facile efficient regeneration methods for SCR catalysts are proposed.

Keywords： flue gas     DeNO<i>xi>     SCR catalyst     poison and regeneration    

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Evaluation of H2 on the Evolution Mechanism of NO<i>xi> Storage and Reduction Article

Pan Wang, Jing Yi, Chuan Sun, Peng Luo, Lili Lei

Engineering 2019, Volume 5, Issue 3,   Pages 568-575 doi: 10.1016/j.eng.2019.02.005

Abstract: prepared by incipient wetness impregnation and experiments were performed to evaluate the influence of H2> storage capability was greatly
enhanced in the temperature range of 250–350 °C,and reached a maximum value of 315.3 μmol·g−1cat at 350 °C,showed that NOx storage efficiency and conversion were increased when the time of H2 exposure (i.e., 30 s, 45 s, and 60 s) was extended.

Keywords： Pt–Ba–Ce/γ-Al2O3 catalysts     Physicochemical properties     NO<i>xi> storageand reduction     NO<i>xi> emission     H2 reductant    

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Title Author Date Type Operation

A post-GWAS replication study confirming the association of

Shaohua YANG,Chao QI,Yan XIE,Xiaogang CUI,Yahui GAO,Jianping JIANG,Li JIANG,Shengli ZHANG,Qin ZHANG,Dongxiao SUN

Journal Article

Development of an H reduction and moderate oxidation method for 3,5-dimethylpyridine hydrogenation in

Journal Article

Protective efficacy of vaccination with NcMIC3 and NcMIC8 against

Taotao ZHANG, Xiao ZHANG, Qun LIU, Jianhai XU, Jing LIU

Journal Article

Association of gene variants with juvenile amyotrophic lateral sclerosis

Journal Article

Gene delivery into isolated

Nan Zheng, Ziyuan Song, Yang Liu, Lichen Yin, Jianjun Cheng

Journal Article

A novel aldo-keto reductase gene,

Jinxi HUO, Bing DU, Sifan SUN, Shaozhen HE, Ning ZHAO, Qingchang LIU, Hong ZHAI

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Journal Article

<i>NES1i>/<i>KLK10i> and <i>hNISi> gene therapy enhanced iodine-131 internal radiation in PC3 proliferation

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Journal Article

<i>Ni>-Positive ion activated rapid addition and mitochondrial targeting ratiometric fluorescent probesfor <i>in vivoi> cell H2S imaging

Yan Shi, Fangjun Huo, Yongkang Yue, Caixia Yin

Journal Article

<i>RR1i> and <i>RR2i> gene deletion affects the immunogenicity of a live attenuated pseudorabies

Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN

Journal Article

NO<i>xi> and H2S formation in the reductive zone of air-staged combustion of

Jinzhi CAI, Dan LI, Denggao CHEN, Zhenshan LI

Journal Article

<i>H. sinensisi> mycelium inhibits epithelial-mesenchymal transition by inactivating

Li Lu, Haiyan Zhu, Hailin Wang, Huaping Liang, Yayi Hou, Huan Dou

Journal Article

A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome

Journal Article

Chemical poison and regeneration of SCR catalysts for NO<i>xi>

Junhua LI,Yue PENG,Huazhen CHANG,Xiang LI,John C. CRITTENDEN,Jiming HAO

Journal Article

Evaluation of H2 on the Evolution Mechanism of NO<i>xi> Storage and Reduction

Pan Wang, Jing Yi, Chuan Sun, Peng Luo, Lili Lei

Journal Article